Welcome! The Backus Lab is a young chemical biology research group at UCLA. We investigate how protein function and cellular fate can be studied and manipulated by chemical probes. By developing new methods that combine chemical biology, genomics, and proteomics, we aim to identify functional, disease-linked, and probe-accessible pockets in human proteins. Current applications of our methods include: (i) the production of probes to alter protein interactions, (ii) precision anti-cancer probes, and (iii) probes that enhance T cell proliferation.
4/20 First ChemRxiv Preprint!
2/20 Keri receives an endowed chair. Thanks to the Kolin family for supporting our work.
2/20 The lab welcomes Lisa back to start her PhD.
1/20 Thanks to the V Foundation for supporting our work!
1/20 Caspase-8 story is published in ACS Chem Bio!
1/2/2020 For the lab's second birthday, we welcome Edgar, Holly, and Ashley for rotations and Nik back to start his PhD.
11/2019 Excited to welcome Nik and Baldwin for the second fall rotation!
09/2019 Kelly, Evan, and Becky join us for the first fall rotation. Welcome!
08/2019 Welcome to Billy, Michael, and Lisa, our three summer rotation students.
08/2019 First Preprint!
07/2019 First lab PhD candidate! Jose passes his qualifying exam.
07/2019 The lab bids farewell to Brie. Best of luck with the move back East!
07/2019 Keri is selected for the DARPA Young Faculty Award. Thanks to DARPA and the DOD for funding our work!
07/2019 The lab welcomes CSST student, DeRui, for the summer.
06/2019 Congrats to Sean on the new position. We wish you the best of luck at Ampac Fine Chemicals.
06/2019 Ernest is selected for the CMB training grant. Congrats!
06/2019 The lab is excited to welcome Heta back to start her PhD.
06/2019 Marina graduates with honors.
06/2019 The lab's first review article on covalent immunomodulators is published.
05/2019 Keri is selected as a Beckman Young Investigator. Thanks to the Arnold and Mabel Beckman Foundation for supporting our work!
03/2019 Welcome to Stephanie and Annie, our two new undergraduate researchers.
03/2019 Ernest, Neil, and Sunny join the lab as our first Chem grad students!
02/2019 Congrats to Ernest on the Stone Fellow award!
01/2019 Welcome to Heta and Cindy, our winter BBSB rotation students!
12/2019 The lab is excited to receive seed grant funding for our proteogenomic studies. Thanks to the UCLA Jonsson Comprehensive Cancer Center for the support!
11/2018 Welcome to George, Sunny, and Ernest, our second group of chemistry rotation students.
10/2018 Welcome to Neil, Danielle, and Chloe, our first chemistry rotation students.
08/2018 Sean joins the lab as Postdoc #2!
07/2018 Taylor joins us for the summer.
06/2018 Jian joins the lab as our first Postdoc! Welcome to LA!
06/2018 Maria is selected for the CBI training grant. Congrats!
06/2018 The lab is excited to welcome Maria back to start her PhD!
03/2018 Jose joins the lab as our first graduate student.
01/2018 Backus Lab established! Brie and Sam join as our founding members.