Publications
At UCLA
Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity
Xu JH, Eberhardt, J, Hill-Payne B, Eberhardt J, González-Páez GE, Castellón JO, Cravatt, BF, Forli S#, Wolan DW#, Backus KM#. (2019) bioRxiv 721951 doi: 10.1101/721951; #co-corresponding author.(link)
Opportunities and challenges for the development of covalent chemical immunomodulators
Backus KM, Jian Cao, Sean Maddox, Bioorganic and Medicinal Chemistry. (2019) pii: S0968-0896(19)30222-6 (link)
Applications of Reactive Cysteine Profiling
Backus KM, (2018) In: . Current Topics in Microbiology and Immunology. Springer, Berlin, Heidelberg (link)
Before UCLA
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
Bar-Peled L., Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF, Cell. 171(3):696-709 (2017) doi: 10.1016/j.cell.2017.08.051 (link)
Proteome-wide assessment of lysine reactivity and ligandability
Hacker, SM*#, Backus, KM*#, Lazear, MR, Forli, S, Correia, B, Cravatt, BF#, Nature Chemistry (2017) *co-first authorship; #co-corresponding author (link)
Hacker, SM*#, Backus, KM*#, Lazear, MR, Forli, S, Correia, B, Cravatt, BF#, Nature Chemistry (2017) *co-first authorship; #co-corresponding author (link)
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases
Guo, CJ, Chang, F-Y, Wyche, TP, Backus, KM, Acker, TM, Funabashi, M, Taketani, M, Donia, MS, Nayfach, S, Pollard, KS., Cravatt, BF, Craik, CS, Clardy, J, Voigt, CA, Fischbach, MA, Cell 168(3): 517-526 (2017) doi: 10.1016/j.cell.2016.12.021(link)
Guo, CJ, Chang, F-Y, Wyche, TP, Backus, KM, Acker, TM, Funabashi, M, Taketani, M, Donia, MS, Nayfach, S, Pollard, KS., Cravatt, BF, Craik, CS, Clardy, J, Voigt, CA, Fischbach, MA, Cell 168(3): 517-526 (2017) doi: 10.1016/j.cell.2016.12.021(link)
A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A
Touchette, MH, Bai, L, Van Vlack, ER, Cognetta, AB, Previti, ML, Backus, KM, Martin, DW, Cravatt, BF, Seeliger, JC ACS. Infec. Dis. 3(5):336-348 (2017) doi: 10.1021/acsinfecdis.6b00179 (link)
Touchette, MH, Bai, L, Van Vlack, ER, Cognetta, AB, Previti, ML, Backus, KM, Martin, DW, Cravatt, BF, Seeliger, JC ACS. Infec. Dis. 3(5):336-348 (2017) doi: 10.1021/acsinfecdis.6b00179 (link)
Covalent Modifiers of the Vacuolar ATPase
Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C., J. Am. Chem. Soc. 139(2):639–642 (2017) doi: 10.1021/jacs.6b12511 (link)
Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C., J. Am. Chem. Soc. 139(2):639–642 (2017) doi: 10.1021/jacs.6b12511 (link)
Chemical proteomic profiling of human methyltransferases
Horning, B, Suciu, M, Ghadiri, D, Ulanovskaya, O, Lum, K, Backus, K, Brown, S, Rosen, H, Cravatt, B, J. Am. Chem. Soc. 138(40):13335-13343 (2016) DOI: 10.1021/jacs.6b07830 (link)
Horning, B, Suciu, M, Ghadiri, D, Ulanovskaya, O, Lum, K, Backus, K, Brown, S, Rosen, H, Cravatt, B, J. Am. Chem. Soc. 138(40):13335-13343 (2016) DOI: 10.1021/jacs.6b07830 (link)
Chemical proteomic map of dimethylfumarate-sensitive cysteines in primary human T cells
Blewett, M, Xie, J, Zaro, B, Backus, KM, Altman, A, Teijaro, J, Cravatt, BF Science Signaling, 9(445):rs10 (2016) doi: 10.1126/scisignal.aaf7694 (link)
Blewett, M, Xie, J, Zaro, B, Backus, KM, Altman, A, Teijaro, J, Cravatt, BF Science Signaling, 9(445):rs10 (2016) doi: 10.1126/scisignal.aaf7694 (link)
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
Briggs, KJ, Koivunen, P, Cao, S, Backus, KM, Olenchock, BA, Patel H, Zhang, Q, Signoretti, S., Gerfen, GJ, Richardson, AL, Witkiewicz, AK, Cravatt, BF, Clardy, J, Kaelin, Jr, WG Cell 166(1):126-39 (2016) doi: 10.1016/j.cell.2016.05.042 (link)
Briggs, KJ, Koivunen, P, Cao, S, Backus, KM, Olenchock, BA, Patel H, Zhang, Q, Signoretti, S., Gerfen, GJ, Richardson, AL, Witkiewicz, AK, Cravatt, BF, Clardy, J, Kaelin, Jr, WG Cell 166(1):126-39 (2016) doi: 10.1016/j.cell.2016.05.042 (link)
Proteome-wide covalent ligand discovery in native biological systems
Backus, KM*#, Correia, B*, Lum, K., Forli, S, Horning, B, González-Páez, GE, Chatterjee, S, Lanning, BR, Teijaro, JR, Olson, AJ, Wolan, DW, Cravatt, BF, Nature 534(7608):570-4 (2016) *co-first authorship; #co-corresponding author doi: 10.1038/nature18002 (link)
Backus, KM*#, Correia, B*, Lum, K., Forli, S, Horning, B, González-Páez, GE, Chatterjee, S, Lanning, BR, Teijaro, JR, Olson, AJ, Wolan, DW, Cravatt, BF, Nature 534(7608):570-4 (2016) *co-first authorship; #co-corresponding author doi: 10.1038/nature18002 (link)
The Three Mycobacterium tuberculosis Antigen 85 Isoforms have Unique Substrates and Activities Determined by Non-active Site Regions
Backus, KM, Dolan, M, Barry, Barry, CS, Joe, M, McPhie, P, Boshoff, HM, Lowary, TL, Davis, BG#, Barry, CE III#, J. Biol. Chem. 289(36):25041-53 (2014) #co-corresponding author doi: 10.1074/jbc.M114.581579 (link)
Backus, KM, Dolan, M, Barry, Barry, CS, Joe, M, McPhie, P, Boshoff, HM, Lowary, TL, Davis, BG#, Barry, CE III#, J. Biol. Chem. 289(36):25041-53 (2014) #co-corresponding author doi: 10.1074/jbc.M114.581579 (link)
ESI-MS Assay of M. tuberculosis Cell Wall Antigen 85 Enzymes Permits Substrate Profiling and Design of a Mechanism-Based Inhibitor
Barry, CS, Backus, KM, Barry, CS III, Davis, BG, J. Am. Chem. Soc. 133(34):13232-5 (2011) doi: 10.1021/ja204249p (link)
Barry, CS, Backus, KM, Barry, CS III, Davis, BG, J. Am. Chem. Soc. 133(34):13232-5 (2011) doi: 10.1021/ja204249p (link)
Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis
Backus, K.M., Boshoff, H., Barry, C.T., Boutureira, O., Patel, M., D’Hooge, F., Lee, S., Kapil, T., Via, LE, Barry, CE III#, Davis, BG#, Nat. Chem. Biol. 7(4): 228-235 (2011) #co-corresponding author doi: 10.1038/nchembio.539 (link)
Backus, K.M., Boshoff, H., Barry, C.T., Boutureira, O., Patel, M., D’Hooge, F., Lee, S., Kapil, T., Via, LE, Barry, CE III#, Davis, BG#, Nat. Chem. Biol. 7(4): 228-235 (2011) #co-corresponding author doi: 10.1038/nchembio.539 (link)
Book Chapters
Mycolic Acid/Cyclopropane Fatty Acid/Fatty Acid Biosynthesis and Health Relations
Kastrinsky, D.B., McBride, N.S., Backus, K.M., Leblanc, J.J., Barry, C.E.III In:Comprehensive Natural Products Chemistry II, Mander L, Liu H-w, editors. Vol. 1. Elsevier; Oxford. pp. 65–146 (2010) (link)
Kastrinsky, D.B., McBride, N.S., Backus, K.M., Leblanc, J.J., Barry, C.E.III In:Comprehensive Natural Products Chemistry II, Mander L, Liu H-w, editors. Vol. 1. Elsevier; Oxford. pp. 65–146 (2010) (link)
Patents
Cysteine Reactive Probes and Uses Thereof
Backus K.M., Correia, B., Blewett, M.M., Cravatt, B.F., U.S. Patent US2017070611A1 Filed Oct. 21, 2016 and published Apr. 27, 2017
Backus K.M., Correia, B., Blewett, M.M., Cravatt, B.F., U.S. Patent US2017070611A1 Filed Oct. 21, 2016 and published Apr. 27, 2017
Cysteine-Reactive Ligand Discovery in Proteomes
Wang, C., Backus K.M., Cravatt, B.F. U.S. Patent EP3033625A1 Filed Aug. 13, 2013 and published Oct. 18, 2015
Wang, C., Backus K.M., Cravatt, B.F. U.S. Patent EP3033625A1 Filed Aug. 13, 2013 and published Oct. 18, 2015
Detection of Mycobacteria
Backus, K. M., Boshoff, H., Davis, B.G., Barry, C.E. U.S. Patent 20120263649A1 Filed Sept. 11, 2009 and published Oct. 18, 2012
Backus, K. M., Boshoff, H., Davis, B.G., Barry, C.E. U.S. Patent 20120263649A1 Filed Sept. 11, 2009 and published Oct. 18, 2012
